製品の概要

  • 製品名Compound 401
  • 製品の詳細
    Selective, reversible DNA-dependent protein kinase and mTOR inhibitor
  • 生理活性の詳細Selective, reversible DNA-dependent protein kinase and mTOR inhibitor (IC50 values are 0.28 and 5.3 μM respectively). No affinity for PI3K, ATM and ATR (IC50 values are >100 μM). Able to induce apoptosis in vitro. Cell-permeable.
  • 精製度> 99%

製品の特性

  • 体系名2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
  • 分子量281.31
  • 構造式Chemical Structure
  • 分子式C16H15N3O2
  • CAS 番号168425-64-7
  • PubChem 登録番号10039361
  • 保存方法Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 10 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記O=C2C=C(N=C1c3ccccc3C=CN12)N4CCOCC4
  • 由来

    Synthetic

  • 研究分野

    Compound 401 (ab120968) 使用論文

    This product has been referenced in:
    • Ballou LM  et al. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem 282:24463-70 (2007). Read more (PubMed: 17562705) »
    • Griffin RJ  et al. Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. J Med Chem 48:569-85 (2005). Read more (PubMed: 15658870) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"