Anti-COMP 抗体 [MA37C94 (HC484D1)] (ab11056)


  • 製品名Anti-COMP antibody [MA37C94 (HC484D1)]
    COMP 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [MA37C94 (HC484D1)] to COMP
  • 特異性Ab11056 recognises human COMP.
  • アプリケーション適用あり: WB, IHC-Fr, IHC-P, ELISA, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human cartilage derived COMP

  • エピトープThe antibody recognises an epitope located in the central portion of the molecule. Unfortunately, we do not have information regarding the exact region.
  • 特記事項Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.



Our Abpromise guarantee covers the use of ab11056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution.
IHC-Fr Use at an assay dependent dilution.
IHC-P Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.


  • 機能May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
  • 組織特異性Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
  • 関連疾患Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 (EDM1) [MIM:132400]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types.
    Defects in COMP are the cause of pseudoachondroplasia (PSACH) [MIM:177170]. PSAC is a dominantly inherited chondrodysplasia characterized by short stature and early-onset osteoarthrosis. PSACH is more severe than EDM1 and is recognized in early childhood.
  • 配列類似性Belongs to the thrombospondin family.
    Contains 4 EGF-like domains.
    Contains 1 TSP C-terminal (TSPC) domain.
    Contains 8 TSP type-3 repeats.
  • 発生段階Present during the earliest stages of limb maturation and is later found in regions where the joints develop.
  • ドメインThe cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.
    The TSP C-terminal domain mediates interaction with FN1 and ACAN.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) antibody
    • Cartilage oligomeric matrix protein antibody
    • Cartilage oligomeric matrix protein precursor antibody
    • COMP antibody
    • COMP_HUMAN antibody
    • EDM 1 antibody
    • EDM1 antibody
    • EPD 1 antibody
    • EPD1 antibody
    • Epiphyseal dysplasia 1 antibody
    • Epiphyseal dysplasia 1 multiple antibody
    • Epiphyseal dysplasia multiple 1 antibody
    • MED antibody
    • MGC13181 antibody
    • MGC149768 antibody
    • PSACH antibody
    • pseudoachondroplasia (epiphyseal dysplasia 1, multiple) antibody
    • Pseudoachondroplasia antibody
    • THBS 5 antibody
    • THBS5 antibody
    • Thrombospondin 5 antibody
    • Thrombospondin-5 antibody
    • Thrombospondin5 antibody
    • TSP5 antibody
    see all

Anti-COMP antibody [MA37C94 (HC484D1)] (ab11056) 使用論文

This product has been referenced in:
  • Bieback K  et al. Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements. Tissue Eng Part A 16:3467-84 (2010). WB ; Human . Read more (PubMed: 20572797) »
  • Di Cesare PE  et al. Expression of cartilage oligomeric matrix protein (COMP) by embryonic and adult osteoblasts. J Orthop Res 18:713-20 (2000). Read more (PubMed: 11117291) »

See all 3 Publications for this product

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: RT°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Tris pH 9.0, microwave
Sample Human Tissue sections (human cartilage)
Specification human cartilage
Permeabilization Yes - 0.2% Triton X-100 and PBS
Fixative Formaldehyde

Dr. Steffen Rickelt

Verified customer

投稿 Mar 19 2014


Ablaufdatum: 22. Oktober 2012

Es freut mich zu hören, dass Sie unser Angebot unseren Antikörper ab11056 in Rind zu testen, annehmen möchten. Wie am Telefon besprochen, können Sie den Guts...

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I am sorry that this antibody did not perform as stated on the datasheet, I have asked our Finance department to issue a credit note for you. The credit note may be used in one of the following ways:

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I"m sorry this vial of ab11056 is giving Xiangyuan trouble. I am happy to provide a refund if this antibody has been purchased within the last 6 months or so. I will just need a PO number or Abcam order reference n...

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Thank you for your enquiry. The antibody ab11056 is a tissue culture supernatant, therefore we can't give a precise concentration. Supernatants will typically be between 10 and 50 ug/ml specific antibody. IHC staining is described in: Di Cesare ...

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