製品の概要

  • 製品名Anti-COLQ antibody
    COLQ 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to COLQ
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Cow
  • 免疫原

    A region within synthetic peptide: MVVLNPMTLG IYLQLFFLSI VSQPTFINSV LPISAALPSL DQKKRGGHKA, corresponding to N terminal amino acids 1-50 of Human COLQ.

  • ポジティブ・コントロール
    • HepG2 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab49190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay 1/312500.

ターゲット情報

  • 機能Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
  • 組織特異性Found at the end plate of skeletal muscle.
  • 関連疾患Defects in COLQ are the cause of congenital myasthenic syndrome Engel type (CMSE) [MIM:603034]; also known as end-plate acetylcholinesterase deficiency or congenital myasthenic syndrome type IC (CMS-IC). CMSE is a rare autosomal recessive congenital myasthenic syndrome characterized by onset during childhood, generalized weakness, abnormal fatigability on exertion, refrectoriness to acetylcholinesterase drugs, decremental electromyographic response and morphological abnormalities of the neuromuscular junctions.
  • 配列類似性Belongs to the COLQ family.
    Contains 2 collagen-like domains.
  • ドメインThe proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.
  • 翻訳後修飾The triple-helical tail is stabilized by disulfide bonds at each end.
  • 細胞内局在Cell junction > synapse.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acetylcholinesterase collagen-like tail subunit isoform I antibody
    • Acetylcholinesterase collagenic tail peptide antibody
    • Acetylcholinesterase collagenic tail peptide precursor antibody
    • Acetylcholinesterase-associated collagen antibody
    • AChE Q subunit antibody
    • asymmetric acetylcholinesterase antibody
    • Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase antibody
    • Colq antibody
    • COLQ_HUMAN antibody
    • EAD antibody
    • OTTHUMP00000209566 antibody
    • OTTHUMP00000209567 antibody
    • single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase antibody
    see all

Anti-COLQ antibody 画像

  • Anti-COLQ antibody (ab49190) at 1.25 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution
    Developed using the ECL technique

    Predicted band size : 48 kDa
    Observed band size : 48 kDa

Anti-COLQ antibody (ab49190) 使用論文

ab49190 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"