製品の概要

  • 製品名Anti-Collagen VIII alpha 1 antibody
    Collagen VIII alpha 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Collagen VIII alpha 1
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rabbit, Human
  • 免疫原

    A synthetic peptide corresponding to C-terminal residues of human Collagen VIII alpha 1

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab58776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent concentration. Predicted molecular weight: 73 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in artherogenesis.
      Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
    • 組織特異性Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.
    • 配列類似性Contains 1 C1q domain.
    • 翻訳後修飾Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
      Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin.
    • 細胞内局在Secreted > extracellular space > extracellular matrix > basement membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • C3orf7 antibody
      • CO8A1_HUMAN antibody
      • COL8A1 antibody
      • Collagen alpha 1(VIII) chain [Precursor] antibody
      • Endothelial collagen antibody
      • MGC9568 antibody
      • Vastatin antibody
      see all

    Anti-Collagen VIII alpha 1 antibody (ab58776) 使用論文

    This product has been referenced in:
    • Loeffler I  et al. Type VIII Collagen Modulates TGF-{beta}1-induced Proliferation of Mesangial Cells. J Am Soc Nephrol 22:649-63 (2011). WB ; Mouse . Read more (PubMed: 21372207) »
    • Todorovic V  et al. Detection of differentially expressed basal cell proteins by mass spectrometry. Mol Cell Proteomics 9:351-61 (2010). WB ; Mouse . Read more (PubMed: 19955077) »

    See all 3 Publications for this product

    Product Wall

    Yes, I will let you know.

    Thank you so much for your patience and understanding!

    Thank you for contacting us.

    I have good news: the peptide is available for sale, but is currently backordered for 3 weeks.
    Once I have more information about the catalog number and datasheet I will let you know - hopefully by the end o...

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    Thank you for your inquiry.  A cross-reaction of this antibody with the collagen alpha2 (VIII) chain was not specifically tested. But I can confirm that a cross-reaction is very unlikely because the immunogen sequence only shares 66% homology with al...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"