製品の概要

  • 製品名Anti-Collagen VII antibody [LH7.2]
    Collagen VII 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [LH7.2] to Collagen VII
  • 特異性This antibody shows no cross-reaction with Type I, II, III, IV, and V collagens, laminin, and fibronectin. It reacts with the basement membrane zone of stratified squamous epithelia. It is useful in differentiating invasive from non-invasive melanoma through clear visualization of appearance and integrity of epidermal basement membrane. It is also helpful in the identification of recessive Dystrophic Epidermolysis Bullosa (RDEB) in which Type VII collagen is defective.
  • アプリケーション適用あり: IHC-Fr, Electron Microscopy, ICC/IFmore details
  • 種交差性
    交差種: Sheep, Goat, Guinea pig, Cow, Human, Pig, Monkey, Marmoset (common)
  • 免疫原

    Insoluble fractions of Human neonatal foreskin epidermal cells.

  • エピトープOn non-helical (non-collagenous) C-terminal region of collagen VII and is resistant to collagenase, trypsin, pronase, neuraminidase, chondroitinase, and hyaluronidase. However, it is lost by digestion of collagen VII with pepsin.
  • ポジティブ・コントロール
    • Normal skin.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 10mM PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)Purified from the ascites fluid by Protein G chromatography.
  • ポリ/モノモノクローナル
  • クローン名LH7.2
  • アイソタイプIgG1
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab80790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration. PubMed: 21939396
Electron Microscopy Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
  • 関連疾患Epidermolysis bullosa acquisita (EBA) is an autoimmune acquired blistering skin disease resulting from autoantibodies to type VII collagen.
    Epidermolysis bullosa dystrophica, autosomal dominant
    Epidermolysis bullosa dystrophica, autosomal recessive
    Epidermolysis bullosa dystrophica, Pasini type
    Epidermolysis bullosa dystrophica, Hallopeau-Siemens type
    Transient bullous dermolysis of the newborn
    Epidermolysis bullosa dystrophica, pretibial type
    Epidermolysis bullosa dystrophica, Bart type
    Epidermolysis bullosa pruriginosa
    Nail disorder, non-syndromic congenital, 8
    Epidermolysis bullosa dystrophica, with subcorneal cleavage
  • 配列類似性Contains 1 BPTI/Kunitz inhibitor domain.
    Contains 9 fibronectin type-III domains.
    Contains 2 VWFA domains.
  • 翻訳後修飾Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 細胞内局在Secreted > extracellular space > extracellular matrix > basement membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha 1 type VII collagen antibody
    • CO7A1_HUMAN antibody
    • Col7a1 antibody
    • Collagen alpha 1(VII) chain antibody
    • Collagen alpha-1(VII) chain antibody
    • Collagen type VII alpha 1 antibody
    • Collagen VII alpha 1 polypeptide antibody
    • CollagenVII antibody
    • EBD 1 antibody
    • EBD1 antibody
    • EBDCT antibody
    • EBR 1 antibody
    • EBR1 antibody
    • LC collagen antibody
    • Long chain collagen antibody
    • Long-chain collagen antibody
    see all

Anti-Collagen VII antibody [LH7.2] (ab80790) 使用論文

This product has been referenced in:
  • Eldardiri M  et al. Wound contraction is significantly reduced by the use of microcarriers to deliver keratinocytes and fibroblasts in an in vivo pig model of wound repair and regeneration. Tissue Eng Part A 18:587-97 (2012). IHC-Fr ; Pig . Read more (PubMed: 21939396) »
  • Kirkham N  et al. Type VII collagen antibody LH 7.2 identifies basement membrane characteristics of thin malignant melanomas. J Pathol 157:243-7 (1989). ICC/IF, Electron Microscopy ; Human, Cow, Goat, Guinea pig, Marmoset (common), Monkey, Pig, Sheep . Read more (PubMed: 2647941) »

See all 5 Publications for this product

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