製品の概要

  • 製品名Anti-Collagen VI antibody
    Collagen VI 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Collagen VI
  • 特異性Percentage of reactivity with all isoforms of COL6 has not been determined.
  • アプリケーション適用あり: WB, IP, ELISA, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Cow, Human
    交差が予測される動物種: all Mammals
  • 免疫原

    Other Immunogen Type corresponding to Collagen VI. Collagen VI antibody was raised against Collagen Type VI from human and bovine placenta.

  • ポジティブ・コントロール
    • Human breast tissue; Human lung tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 109 kDa.
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能Collagen VI acts as a cell-binding protein.
  • 関連疾患Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • 配列類似性Belongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • 翻訳後修飾Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha 1 (VI) chain (61 AA) antibody
    • CO6A1_HUMAN antibody
    • COL6A1 antibody
    • COL6A2 antibody
    • COL6A3 antibody
    • Collagen alpha 2(VI) chain antibody
    • Collagen alpha 3(VI) chain antibody
    • Collagen alpha-1(VI) chain antibody
    • Collagen type VI alpha 1 antibody
    • Collagen type VI alpha 2 antibody
    • Collagen type VI alpha 3 antibody
    • Collagen VI alpha 1 polypeptide antibody
    • Collagen VI alpha 2 polypeptide antibody
    • Collagen VI alpha 3 polypeptide antibody
    • CollagenVI antibody
    • Human mRNA for collagen VI alpha 2 C terminal globular domain antibody
    • OPLL antibody
    • PP3610 antibody
    see all

Anti-Collagen VI antibody 画像

  • ab118955 at 2.5 ug/ml staining COL6A1 in formalin fixed paraffin embedded Human breast tissue by immunohistochemistry. Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

  • ab118955 at 2.5 ug/ml staining COL6A1 in paraffin embedded formalin fixed Human lung tissue by immunohistochemistry. Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Collagen VI antibody (ab118955) 使用論文

ab118955 has not yet been referenced specifically in any publications.

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