Anti-Collagen I + Collagen III 抗体 (ab36074)

製品の概要

• 製品名
  Anti-Collagen I + Collagen III antibody
  Collagen I + Collagen III 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Collagen I + Collagen III
• 特異性
  This antibody showa cross reactivity with: Bovine collagen type III 100%; Bovine collagen type I 100%; Bovine collagen type II <3%; Bovine collagen type IV <1%; Bovine collagen type V <1%; Bovine fibronectin and albumin <0.5%; and Bovine immunoglobulin <0.5%.
• アプリケーション
  適用あり: ELISA, ICC/IFmore details
• 種交差性
  交差種: Cow
  
• 免疫原

  Full length native Collagen I + Collagen III proteins (purified) from cow skin.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: None
  Constituents: 0.1M Sodium chloride, 0.01M Sodium phosphate, 0.01M Sodium borate, pH 7.5, 0.1% mannitol.
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  This antibody was affinity isolated. It was purified by affinity chromatography on immobilized Collagen I + III.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Proteins
  • Collagen

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 関連性
  Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
• 細胞内局在
  Secreted
• 参照データベース
  • Entrez Gene: 282187 Cow
  • Entrez Gene: 282188 Cow
  • Entrez Gene: 282190 Cow
  • SwissProt: P02465 Cow
  • SwissProt: P04258 Cow
• 別名
  • Alpha 1 type I collagen antibody
  • Alpha 2 type I collagen antibody
  • COL1A1 antibody

  • COL1A2 antibody
  • COL3A1 antibody
  • Collagen fetal antibody
  • Collagen type I alpha 1 antibody
  • Collagen type I alpha 2 antibody
  • Collagen type III alpha 1 antibody
  • OI4 antibody
  • Type I collagen alpha 1 chain antibody
  • Type I procollagen antibody

  see all

プロトコール

• Immunocytochemistry & immunofluorescence protocols