Anti-Collagen I + II + III + IV + V 抗体 (ab36064)
Key features and details
- Rabbit polyclonal to Collagen I + II + III + IV + V
- Suitable for: ELISA, IHC-Fr, ICC/IF
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Collagen I + II + III + IV + V antibody -
製品の詳細
Rabbit polyclonal to Collagen I + II + III + IV + V -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, IHC-Fr, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Full length native Collagen I + II + III + IV + V proteins (purified) from human placenta.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.50
Constituents: 0.1% Dextran, 0.87% Sodium chloride, 0.164% Sodium phosphate, 0.1% Mannitol -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
This antibody is affinity isolated. It was purified by affinity chromatography on immobilized Collagen types I-V. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab36064の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
|
|
ICC/IF |
Use at an assay dependent concentration.
|
特記事項 |
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ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Type I collagen is a member of group I collagen (fibrillar forming collagen). -
組織特異性
Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. -
関連疾患
Caffey disease
Ehlers-Danlos syndrome, classic type
Ehlers-Danlos syndrome 7A
Osteogenesis imperfecta 1
Osteogenesis imperfecta 2
Osteogenesis imperfecta 3
Osteogenesis imperfecta 4
Osteoporosis
A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. -
配列類似性
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 VWFC domain. -
ドメイン
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. -
翻訳後修飾
Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group. -
細胞内局在
Secreted, extracellular space, extracellular matrix. - Information by UniProt
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参照データベース
- Entrez Gene: 1277 Human
- Entrez Gene: 1280 Human
- Entrez Gene: 1281 Human
- Entrez Gene: 1282 Human
- Entrez Gene: 1289 Human
- Omim: 120130 Human
- Omim: 120140 Human
- Omim: 120150 Human
see all -
別名
- Alpha-1 type I collagen antibody
- CO1A1_HUMAN antibody
- COL1A1 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab36064 は 5 報の論文で使用されています。
- Lau S et al. Venous and Arterial Endothelial Cells from Human Umbilical Cords: Potential Cell Sources for Cardiovascular Research. Int J Mol Sci 22:N/A (2021). PubMed: 33478148
- Luong B et al. The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen. PLoS One 13:e0203053 (2018). PubMed: 30204757
- Schwenk R et al. The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells. Oncotarget 8:77622-77633 (2017). PubMed: 29100413
- Sur S et al. Synergistic regulation of cerebellar Purkinje neuron development by laminin epitopes and collagen on an artificial hybrid matrix construct. Biomater Sci 2:903-914 (2014). PubMed: 25530849
- Trescher K et al. Test system for evaluating the influence of polymer properties on primary human keratinocytes and fibroblasts in mono- and coculture. J Biotechnol 166:58-64 (2013). PubMed: 23643480