製品の概要

  • 製品名Anti-COL6A1 antibody
    COL6A1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to COL6A1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from the internal region of Human COL6A1.

  • ポジティブ・コントロール
    • Human heart tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab111819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Collagen VI acts as a cell-binding protein.
  • 関連疾患Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • 配列類似性Belongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • 翻訳後修飾Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha 1 (VI) chain (61 AA) antibody
    • CO6A1_HUMAN antibody
    • COL6A1 antibody
    • Collagen alpha-1(VI) chain antibody
    • Collagen VI, alpha 1 polypeptide antibody
    • Collagen, intimal short chain collagen antibody
    • Collagen, type VI, alpha 1 antibody
    • OPLL antibody
    • OTTHUMP00000115501 antibody
    see all

Anti-COL6A1 antibody 画像

  • ab111819 at 1/50 dilution staining COL6A1 in paraffin-embedded Human heart tissue by Immunohistochemistry. The image on the right is treated with synthesized peptide.

Anti-COL6A1 antibody (ab111819) 使用論文

ab111819 has not yet been referenced specifically in any publications.

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