製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-DIKDRSTLGEK
    • 領域
      142 to 152

関連製品

特性

Our Abpromise guarantee covers the use of ab45798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Cofilin 2 antibody (ab39985)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • CFL 2
    • CFL2
    • COF2_HUMAN
    • Cofilin
    • Cofilin 2 muscle
    • Cofilin muscle
    • Cofilin muscle isoform
    • Cofilin-2
    • Cofilin2
    • muscle isoform
    • NEM 7
    • NEM7
    see all
  • 機能
    Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
  • 組織特異性
    Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
  • 関連疾患
    Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 7 presents at birth with hypotonia and generalized weakness. Major motor milestones are delayed, but independent ambulation is achieved.
  • 配列類似性
    Belongs to the actin-binding proteins ADF family.
    Contains 1 ADF-H domain.
  • 翻訳後修飾
    The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
  • 細胞内局在
    Nucleus matrix. Cytoplasm > cytoskeleton.
  • Information by UniProt

Cofilin 2 peptide (142-152) (ab45798) 使用論文

ab45798 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45798.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録