製品の概要

  • 製品名Anti-COCH antibody
    COCH 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to COCH
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-494 of Human COCH

  • ポジティブ・コントロール
    • COCH transfected 293T cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 54 kDa.

ターゲット情報

  • 機能Plays a role in the control of cell shape and motility in the trabecular meshwork.
  • 組織特異性Expressed in inner ear structures; the cochlea and the vestibule.
  • 関連疾患Defects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9) [MIM:601369]. DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers.
  • 配列類似性Contains 1 LCCL domain.
    Contains 2 VWFA domains.
  • 翻訳後修飾N-glycosylated.
    A 50 kDa form is created by proteolytic cleavage.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Coagulation factor C homolog, cochlin (Limulus polyphemus) antibody
    • COCH antibody
    • COCH-5B2 antibody
    • COCH_HUMAN antibody
    • COCH5B2 antibody
    • Cochlin antibody
    • DFNA9 antibody
    see all

Anti-COCH antibody 画像

  • All lanes : Anti-COCH antibody (ab72581) at 1/500 dilution

    Lane 1 : COCH transfected 293T cell lysate
    Lane 2 : non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

Anti-COCH antibody (ab72581) 使用論文

ab72581 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab72581.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"