製品の概要

  • 製品名CNQX disodium salt
  • 製品の詳細
    AMPA / kainate antagonist; water soluble
  • 生理活性の詳細Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.

    Also available in simple stock solutions (ab144488) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度> 99%

法規制情報

製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab120044 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    CNQX disodium salt 画像

    • ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with CNQX disodium salt (ab120044), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of CNQX disodium salt, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120044 (CNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    CNQX disodium salt (ab120044) 使用論文

    This product has been referenced in:
    • Long SK  et al. Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro. Br J Pharmacol 100:850-4 (1990). Read more (PubMed: 1976402) »
    • Honoré T  et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701-3 (1988). Read more (PubMed: 2899909) »
    • Birch PJ  et al. 6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor. Eur J Pharmacol 156:177-80 (1988). Read more (PubMed: 2905271) »

    See all 12 Publications for this product

    Product Wall

    The compound may contain larger granules, which will require more effort to dissolve. We would recommend to use heat and sonication.

    · Heat in a 50°C water bath for approximately 5 minutes
    · Vortex/sonication on removal
    · Repeat as nec...

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    The molecular weight and formula published on our website represent the molecular weight and formula of the product as depicted in the chemical structure displayed on our website. However, molecular weights (and formulae) can vary slightly from batch t...

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    Thank you for contacting Abcam and for your interest in our products.


    Regarding ab120044 and ab120169, we don't use HPLC to purify the product, it is used only to analyse it.Our methods of purification are proprietary. We would therefore ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"