製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CLNK
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 280-308 of Human CLNK (NP_443196.2).

  • ポジティブ・コントロール
    • HepG2 cell line lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファー
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab116287 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab116287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

ターゲット情報

  • 機能
    Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT.
  • 配列類似性
    Contains 1 SH2 domain.
  • ドメイン
    The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
    The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT.
  • 翻訳後修飾
    Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CLNK antibody
    • CLNK_HUMAN antibody
    • Cytokine-dependent hematopoietic cell linker antibody
    • Mast cell immunoreceptor signal transducer antibody
    • MGC159342, antibody
    • MGC35197 antibody
    • MIST antibody
    • RGD1562417 antibody
    see all

画像

  • Anti-CLNK antibody (ab116287) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size : 50 kDa

プロトコール

参考文献

ab116287 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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