製品の概要

  • 製品名Anti-CLN8 antibody
  • 製品の詳細
    Rabbit polyclonal to CLN8
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Horse, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to N terminal amino acids 1-49 (MNPASDGGTS ESIFDLDYAS WGIRSTLMVA GFVFYLGVFV VCHQLSSSLN) , of Human CLN8 (NP_061764)

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab82759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/12500.

ターゲット情報

  • 機能Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
  • 関連疾患Defects in CLN8 are the cause of neuronal ceroid lipofuscinosis type 8 (CLN8) [MIM:600143]. A form of neuronal ceroid lipofuscinosis with onset in childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 8 comprise mixed combinations of granular, curvilinear, and fingerprint profiles.
    Defects in CLN8 are the cause of neuronal ceroid lipofuscinosis type 8 Northern epilepsy variant (CLN8NE) [MIM:610003]. A form of neuronal ceroid lipofuscinosis clinically characterized by epilepsy that presents between 5 and 10 years of age with frequent tonic-clonic seizures followed by progressive mental retardation. Visual loss is not a prominent feature. Intracellular accumulation of autofluorescent material results in curvilinear and granular profiles on ultrastructural analysis.
  • 配列類似性Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • 翻訳後修飾Does not seem to be N-glycosylated.
  • 細胞内局在Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C8orf61 antibody
    • Ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) antibody
    • Cln8 antibody
    • CLN8 gene antibody
    • CLN8_HUMAN antibody
    • EPMR antibody
    • Protein CLN8 antibody
    see all

Anti-CLN8 antibody 画像

  • Anti-CLN8 antibody (ab82759) at 1 µg/ml + HeLa cell lysate at 10 µg with skim milk/ PBS at 5 %

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa
    Observed band size : 43 kDa (why is the actual band size different from the predicted?)

Anti-CLN8 antibody (ab82759) 使用論文

ab82759 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab82759.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"