製品の概要

  • 製品名Anti-CLK4 antibody
    CLK4 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to CLK4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    CLK4 full length human protein.

  • ポジティブ・コントロール
    • CLK4 transfected 293T cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab67936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 62 kDa (predicted molecular weight: 57 kDa).

ターゲット情報

  • 機能Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
  • 組織特異性Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylates on all three types of residues.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI987988 antibody
    • C85119 antibody
    • CDC like kinase 4 antibody
    • CDC-like kinase 4 antibody
    • CLK4 antibody
    • CLK4_HUMAN antibody
    • DKFZp686A20267 antibody
    • Dual specificity protein kinase CLK4 antibody
    • OTTMUSP00000005756; antibody
    • OTTMUSP00000005757 antibody
    • OTTMUSP00000041113 antibody
    • Protein serine threonine kinase Clk4 antibody
    • RP23-9N7.1 antibody
    see all

Anti-CLK4 antibody 画像

  • All lanes : Anti-CLK4 antibody (ab67936) at 1/500 dilution

    Lane 1 : CLK4 transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 57 kDa
    Observed band size : 62 kDa (why is the actual band size different from the predicted?)

Anti-CLK4 antibody (ab67936) 使用論文

ab67936 has not yet been referenced specifically in any publications.

Product Wall

You are welcome. I will gather the information we need for the CLK1 and CLK4 antibodies and will send it as soon as I receive it.

Thank you for your patience. None of our CLK antibodies have been tested against purified protein of other CLK family members. Cross-reactivity of, for instance, a CLK1 antibody with CLK2, 3, or 4 has not been confirmed. The best we can do is p...

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Thank you for contacting us. I am very sorry for the confusion. I performed a BLAST to find out the percentage of homology between the four proteins, and the results are: -CLK1-CLK2: 53.5% -CLK1-CLK3: 14% -CLK1-CLK4: 77% -CLK2-CL...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"