製品の概要

  • 製品名Anti-CLIC1 antibody
    CLIC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CLIC1
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant human CLIC1 protein

  • ポジティブ・コントロール
    • A375 cell line lysates; human prostate carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/50 - 1/100. Predicted molecular weight: 27 kDa.
ELISA 1/1000.
IHC-P 1/10 - 1/50.

ターゲット情報

  • 機能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
  • 組織特異性Expression is prominent in heart, placenta, liver, kidney and pancreas.
  • 配列類似性Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • ドメインMembers of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • 翻訳後修飾Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
  • 細胞内局在Nucleus. Nucleus membrane. Cytoplasm. Cell membrane. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Chloride channel ABP antibody
    • Chloride intracellular channel 1 antibody
    • Chloride intracellular channel protein 1 antibody
    • CLIC 1 antibody
    • CLIC1 antibody
    • CLIC1_HUMAN antibody
    • G6 antibody
    • hRNCC antibody
    • NCC 27 antibody
    • NCC27 antibody
    • Nuclear chloride ion channel 27 antibody
    • Nuclear chloride ion channel protein antibody
    • p64CLCP antibody
    • Regulatory nuclear chloride ion channel protein antibody
    • RNCC protein antibody
    see all

Anti-CLIC1 antibody 画像

  • Anti-CLIC1 antibody (ab76592) at 1/60 dilution + A375 cell line lysates at 35 µg

    Predicted band size : 27 kDa
    Observed band size : 27 kDa
  • ab76592, at a 1/10 dilution, staining CLIC1 in formalin fixed, paraffin embedded human prostate carcinoma tissue by Immunohistochemistry. ab76592 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-CLIC1 antibody (ab76592) 使用論文

ab76592 has not yet been referenced specifically in any publications.

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