機能Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
組織特異性Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.
配列類似性Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. Contains 2 CBS domains.
翻訳後修飾N-glycosylated on several asparagine residues.
細胞内局在Endosome membrane. Detected in detergent-resistant lipid rafts.