製品の概要

  • 製品名Anti-CLCN2 antibody
    CLCN2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to CLCN2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Monkey, Marmoset (common)
  • 免疫原

    Synthetic peptide:

    QQLDEPVNFSDCK

    , corresponding to internal sequence amino acids 777-789 of Human CLCN2 (NP_004357.3).

  • ポジティブ・コントロール
    • HeLa cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab99501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 98 kDa).

ターゲット情報

  • 機能Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
  • 組織特異性Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells.
  • 関連疾患Defects in CLCN2 are associated with susceptibility to idiopathic generalized epilepsy type 11 (IGE11) [MIM:607628]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
    Defects in CLCN2 are the cause of childhood absence epilepsy type 3 (ECA3) [MIM:607682]. ECA3 is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3 Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop.
    Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2) [MIM:607628]. JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic-clonic seizures (GTCS), GTCS on awakening and myoclonic seizures.
    Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8) [MIM:607628]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • 配列類似性Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
    Contains 2 CBS domains.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Chloride Channel 2 antibody
    • Chloride channel protein 2 antibody
    • Chloride channel, voltage sensitive 2 antibody
    • CIC 2 antibody
    • CIC2 antibody
    • ClC-2 antibody
    • CLC2 antibody
    • Clcn2 antibody
    • CLCN2_HUMAN antibody
    • ECA2 antibody
    • ECA3 antibody
    • EG13 antibody
    • EGI11 antibody
    • EGMA antibody
    • EJM6 antibody
    • EJM8 antibody
    • PKA-activated chloride channel antibody
    see all

Anti-CLCN2 antibody 画像

  • Anti-CLCN2 antibody (ab99501) at 0.3 µg/ml + HeLa cell lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 98 kDa

Anti-CLCN2 antibody (ab99501) 使用論文

ab99501 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"