製品の概要

  • 製品名
    Anti-CLCA2 antibody
  • 製品の詳細
    Rabbit polyclonal to CLCA2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Rabbit, Horse, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence amino acids 674-723 (RYFFSFAANG RYSLKVHVNH SPSISTPAHS IPGSHAMYVP GYTANGNIQM) of Human CLCA2 (NP_006527.1).

  • ポジティブ・コントロール
    • THP-1 cell lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab108101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 104 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Play a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
  • 組織特異性
    Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules.
  • 配列類似性
    Belongs to the CLCR family.
    Contains 1 VWFA domain.
  • 翻訳後修飾
    The 141 kDa mature form is shedded, producing a 109 kDa form and a 35 kDa form.
    N-glycosylated.
  • 細胞内局在
    Cell membrane. Basal cell membrane. Cell junction and Secreted. Remains associated to the 35 kDa form until an unidentified event triggers the release.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 35 kDa form antibody
    • CaCC-3 antibody
    • CaCC3 antibody
    • Calcium-activated chloride channel family member 2 antibody
    • Calcium-activated chloride channel protein 3 antibody
    • Calcium-activated chloride channel regulator 2 antibody
    • Calcium-activated chloride channel-2 antibody
    • Chloride channel, calcium activated, family member 2 antibody
    • Clca2 antibody
    • CLCA2_HUMAN antibody
    • hCaCC-3 antibody
    • hCLCA2 antibody
    see all

Anti-CLCA2 antibody 画像

  • Anti-CLCA2 antibody (ab108101) at 1 µg/ml + THP-1 cell lysate at 10 µg

    Predicted band size : 104 kDa

プロトコール

Anti-CLCA2 antibody (ab108101) 使用論文

ab108101 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab108101.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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