製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-TVTSKTNKDTSK
    • 領域
      592 to 603

特性

Our Abpromise guarantee covers the use of ab45746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

関連情報

  • 別名
    • CaCC
    • CaCC-1
    • CACC1
    • Calcium dependent chloride channel 1
    • Calcium-activated chloride channel family member 1
    • Calcium-activated chloride channel protein 1
    • Calcium-activated chloride channel regulator 1
    • Chloride channel calcium activated family member 1
    • Chloride channel regulator 1
    • CLCA family member 1 chloride channel regulator
    • CLCA1
    • CLCA1_HUMAN
    • CLCRG1
    • GOB5
    • hCaCC-1
    • hCLCA1
    see all
  • 機能
    May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
  • 組織特異性
    Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
  • 配列類似性
    Belongs to the CLCR family.
    Contains 1 VWFA domain.
  • 翻訳後修飾
    Glycosylated.
    The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.
  • 細胞内局在
    Secreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
  • Information by UniProt

参考文献

ab45746 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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