製品の概要
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製品名Anti-CLCA1 antibody
CLCA1 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to CLCA1
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由来種Rabbit
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アプリケーション適用あり: WB, IHC-Pmore details
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種交差性交差種: Human
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免疫原
Synthetic peptide, corresponding to a region within amino acids 542-643 of Human CLCA1 (NP_001276).
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ポジティブ･コントロール
- A431 whole cell lysate. Sections of gastric CA.
法規制情報
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーPreservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol, 1% BSA, 1 x PBS, pH 7.0 -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab96131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 100 kDa. | |
| IHC-P | 1/100 - 1/250. |
ターゲット情報
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機能May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
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組織特異性Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
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配列類似性Belongs to the CLCR family.
Contains 1 VWFA domain. -
翻訳後修飾Glycosylated.
The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. -
細胞内局在Secreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
- Information by UniProt
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参照データベース
- Entrez Gene: 1179 Human
- Omim: 603906 Human
- SwissProt: A8K7I4 Human
- Unigene: 194659 Human
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別名
- CaCC antibody
- CaCC-1 antibody
- CACC1 antibody
see all
画像
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Western blot - Anti-CLCA1 antibody (ab96131)Anti-CLCA1 antibody (ab96131) at 1/1000 dilution + A431 whole cell lysate at 30 µg
Predicted band size: 100 kDa
7.5% SDS PAGE -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLCA1 antibody (ab96131)ab96131 at 1/100 dilution staining CLCA1 in paraffin-embedded Gastric CA by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
参考文献
ab96131 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"