Anti-CLCA1 抗体 (ab96131)

製品の概要

• 製品名
  Anti-CLCA1 antibody
  CLCA1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to CLCA1
• アプリケーション
  適用あり: WB, IHC-Pmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide, corresponding to a region within amino acids 542-643 of Human CLCA1 (NP_001276).

• ポジティブ･コントロール
  • A431 whole cell lysate. Sections of gastric CA.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 1% BSA, 1 x PBS, pH 7.0
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Other

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • A431 membrane extract lysate (ab30134)
  • A431 whole cell lysate (ab7909)

アプリケーション

ターゲット情報

• 機能
  May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
• 組織特異性
  Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
• 配列類似性
  Belongs to the CLCR family.
  Contains 1 VWFA domain.
• 翻訳後修飾
  Glycosylated.
  The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.
• 細胞内局在
  Secreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

• Target information above from: UniProt accession A8K7I4 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 1179 Human
  • Omim: 603906 Human
  • SwissProt: A8K7I4 Human
  • Unigene: 194659 Human
• 別名
  • CaCC antibody
  • CaCC-1 antibody
  • CACC1 antibody

  • Calcium dependent chloride channel 1 antibody
  • Calcium-activated chloride channel family member 1 antibody
  • Calcium-activated chloride channel protein 1 antibody
  • Calcium-activated chloride channel regulator 1 antibody
  • Chloride channel calcium activated family member 1 antibody
  • Chloride channel regulator 1 antibody
  • CLCA family member 1 chloride channel regulator antibody
  • CLCA1 antibody
  • CLCA1_HUMAN antibody
  • CLCRG1 antibody
  • GOB5 antibody
  • hCaCC-1 antibody
  • hCLCA1 antibody

  see all

プロトコール

• Western blot protocols
• Immunohistochemistry protocols