Plays a major role in tight junction-specific obliteration of the intercellular space.
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Belongs to the claudin family.
Cell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
Immunohistochemical analysis of Claudin 7 in paraffin embedded human prostate carcinoma tissue, using ab79481 at a 1/100 dilution in the absence (left image) and presence (right image) of the immunizing peptide.