製品の概要

  • 製品名Anti-Claudin 1 antibody [SP128]
    Claudin 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [SP128] to Claudin 1
  • アプリケーション適用あり: IHC-P, Flow Cytmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Pig
  • 免疫原

    Synthetic peptide corresponding to C-terminus of Human Claudin 1.

  • ポジティブ・コントロール
    • Human liver carcinoma tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.60
    Preservative: 0.1% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • 精製度Protein A purified
  • 特記事項(精製)Purified by Protein A/G
  • ポリ/モノモノクローナル
  • クローン名SP128
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab115783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/200. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Flow Cyt 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
    (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594).
  • 組織特異性Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 関連疾患Ichthyosis-sclerosing cholangitis neonatal syndrome
  • 配列類似性Belongs to the claudin family.
  • 細胞内局在Cell junction, tight junction. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Claudin-1 antibody
    • Claudin1 antibody
    • CLD 1 antibody
    • CLD1 antibody
    • CLD1_HUMAN antibody
    • CLDN 1 antibody
    • Cldn1 antibody
    • ILVASC antibody
    • SEMP 1 antibody
    • SEMP1 antibody
    • Senescence associated epithelial membrane protein 1 antibody
    • Senescence associated epithelial membrane protein antibody
    • Senescence-associated epithelial membrane protein antibody
    see all

Anti-Claudin 1 antibody [SP128] 画像

  • Flow cytometric analysis of rabbit anti-Claudin 1 (SP128) antibody ab115783 (1/100) in HepG2 cells(green) compared to negative control of rabbit IgG (blue).

  • Staining of Human Claudin 1 in a Formalin/PFA-fixed paraffin-embedded section of Human Liver Carcinoma using ab115783 at a dilution of 1/200.

Anti-Claudin 1 antibody [SP128] (ab115783) 使用論文

ab115783 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"