製品の概要

  • 製品名Anti-Claudin 1 antibody
    Claudin 1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Claudin 1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-212 of Human Claudin 1

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab56417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 23 kDa.
IHC-P Use a concentration of 3 µg/ml.

ターゲット情報

  • 機能Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
    (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594).
  • 組織特異性Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 関連疾患Ichthyosis-sclerosing cholangitis neonatal syndrome
  • 配列類似性Belongs to the claudin family.
  • 細胞内局在Cell junction, tight junction. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Claudin-1 antibody
    • Claudin1 antibody
    • CLD 1 antibody
    • CLD1 antibody
    • CLD1_HUMAN antibody
    • CLDN 1 antibody
    • Cldn1 antibody
    • ILVASC antibody
    • SEMP 1 antibody
    • SEMP1 antibody
    • Senescence associated epithelial membrane protein 1 antibody
    • Senescence associated epithelial membrane protein antibody
    • Senescence-associated epithelial membrane protein antibody
    see all

Anti-Claudin 1 antibody 画像

  • Claudin 1 antibody (ab56417) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.


  • Predicted band size : 23 kDa
    Claudin 1 antibody (ab56417) at 1ug/lane + PRC/PRF/5 cell lysate at 25ug/lane.

Anti-Claudin 1 antibody (ab56417) 使用論文

This product has been referenced in:
  • Takahashi S  et al. Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. Hum Pathol 46:1257-66 (2015). IHC-P ; Human . Read more (PubMed: 26208847) »
  • Koda R  et al. Expression of tight junction protein claudin-1 in human crescentic glomerulonephritis. Int J Nephrol 2014:598670 (2014). IF ; Human . Read more (PubMed: 24868462) »

See all 4 Publications for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (mouse pancreas)
Specification mouse pancreas
Fixative Paraformaldehyde
Antigen retrieval step Heat mediated
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 20% · Temperature: 16°C
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投稿 Jul 23 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"