製品の概要

  • 製品名Anti-CLASP1 antibody
    CLASP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CLASP1
  • 特異性Detects endogenous levels of total CLASP1 protein
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from internal region of human CLASP1

  • ポジティブ・コントロール
    • Extracts from Jurkat cells (WB); human testis tissue (IHC-P)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 169 kDa.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
  • 配列類似性Belongs to the CLASP family.
    Contains 7 HEAT repeats.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Golgi apparatus > trans-Golgi network. Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1700030C23Rik antibody
    • 5730583A19Rik antibody
    • B130045P17Rik antibody
    • CLAP1_HUMAN antibody
    • clasp1 antibody
    • CLIP associating protein 1 antibody
    • CLIP associating protein CLASP1 antibody
    • CLIP-associating protein 1 antibody
    • Cytoplasmic linker associated protein 1 antibody
    • Cytoplasmic linker-associated protein 1 antibody
    • DKFZp686D1968 antibody
    • DKFZp686H2039 antibody
    • FLJ33821 antibody
    • FLJ41222 antibody
    • hOrbit1 antibody
    • KIAA0622 antibody
    • MAST1 antibody
    • MGC131895 antibody
    • mKIAA0622 antibody
    • Multiple asters 1 antibody
    • Multiple asters homolog 1 antibody
    • Protein Orbit homolog 1 antibody
    see all

Anti-CLASP1 antibody 画像

  • All lanes : Anti-CLASP1 antibody (ab110010) at 1/500 dilution

    Lane 1 : extracts from Jurkat cells (5-30 ug total protein) with no immunizing peptide
    Lane 2 : extracts from Jurkat cells (5-30 ug total protein) with immunizing peptide (5-10 ug)


    Predicted band size : 169 kDa
  • Immunohistochemistry analysis of paraffin embedded human testis tissue, using ab110010 at 1/50. The picture on the right is treated with the immunizing peptide.

Anti-CLASP1 antibody (ab110010) 使用論文

ab110010 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"