製品の概要

  • 製品名Ciproxifan maleate
  • 製品の詳細
    Potent prototypic H3 inverse agonist / antagonist
  • 生理活性の詳細Potent prototypic H3 inverse agonist / antagonist (pKi = 7.2 nM). Improves attention and wakefulness in vivo. Additionally improves memory function.
  • 精製度> 98%

製品の特性

  • 体系名Cyclopropyl [4-[3-(1H-imidazol-4-yl)propoxy]phenyl]methanone maleate
  • 分子量386.40
  • 構造式Chemical Structure
  • 分子式C16H18N2O2.C4H4O4
  • CAS 番号184025-19-2
  • 保存方法Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記O=C(O)/C=C\C(=O)O.O=C(C1CC1)c3ccc(OCCCc2cncn2)cc3
  • 由来

    Synthetic

  • 研究分野

    Ciproxifan maleate (ab120779) 使用論文

    This product has been referenced in:
    • Bardgett ME  et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem 95:64-72 (2011). Read more (PubMed: 21073971) »
    • Fox GB  et al. Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization. J Pharmacol Exp Ther 305:897-908 (2003). Read more (PubMed: 12606600) »
    • Ligneau X  et al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther 287:658-66 (1998). Read more (PubMed: 9808693) »
    • Felberg NT  et al. CEA family syndrome. Abnormal carcinoembryonic antigen (CEA) levels in asymptomatic retinoblastoma family members. Cancer 37:1397-402 (1976). Read more (PubMed: 1260660) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120779.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"