製品の概要

  • 製品名Anti-Cip4 antibody
    Cip4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cip4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 114-145 of Human Cip4 (NP_004231.1, Q15642).

  • ポジティブ・コントロール
    • K562 cell line lysates

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab123392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 68 kDa.

ターゲット情報

  • 機能Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • 組織特異性Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
  • 配列類似性Belongs to the FNBP1 family.
    Contains 1 FCH domain.
    Contains 1 REM (Hr1) repeat.
    Contains 1 SH3 domain.
  • 翻訳後修飾Tyrosine phosphorylated. Also phosphorylated by PKA.
  • 細胞内局在Cytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cdc42 interacting protein 4 antibody
    • Cdc42 interaction protein 4 long isoform antibody
    • Cdc42-interacting protein 4 antibody
    • CG11341 antibody
    • CG15015 PA antibody
    • Cip 4 antibody
    • CIP4 antibody
    • CIP4_HUMAN antibody
    • DCIP4 antibody
    • hSTP antibody
    • Protein Felic antibody
    • Salt tolerant protein antibody
    • Salt tolerator antibody
    • STOT antibody
    • STP antibody
    • Thyroid hormone receptor interactor 10 antibody
    • Thyroid receptor interacting protein 10 antibody
    • Thyroid receptor-interacting protein 10 antibody
    • TR-interacting protein 10 antibody
    • TRIP 10 antibody
    • TRIP-10 antibody
    • trip10 antibody
    • Truncated Cdc42 interaction protein 4 antibody
    see all

Anti-Cip4 antibody 画像

  • Anti-Cip4 antibody (ab123392) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 68 kDa

Anti-Cip4 antibody (ab123392) 使用論文

ab123392 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"