製品の概要

  • 製品名Cinnabarinic acid
  • 製品の詳細
    Endogenous mGlu4 selective agonist
  • 生理活性の詳細Endogenous selective mGlu4 agonist; generated by autoxidation of the tryptophan metabolite 3-hydroxyanthranilic acid. Activates mGlu4 receptors in transiently transfected HEK293 cells, and is devoid of activity on other mGlu receptor subtypes (mGlu1, 2, 5, 6, 7, and 8). Protects against NMDA-induced excitotoxic cell death.
  • 精製度> 98%

製品の特性

  • 体系名2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
  • 分子量300.23
  • 構造式Chemical Structure
  • 分子式C14H8N2O6
  • CAS 番号606-59-7
  • PubChem 登録番号114918
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 25 mM (requires warming)
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記C1=CC(=C2C(=C1)OC3=CC(=O)C(=C(C3=N2)C(=O)O)N)C(=O)O
  • 由来

    Synthetic

    Cinnabarinic acid (ab120506) 使用論文

    This product has been referenced in:
    • Fazio F  et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol Pharmacol 81:643-56 (2012). Read more (PubMed: 22311707) »
    • Hiramatsu R  et al. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J Cell Biochem 103:42-53 (2008). Read more (PubMed: 17476692) »
    • Manthey MK  et al. Mechanism of reaction of 3-hydroxyanthranilic acid with molecular oxygen. Biochim Biophys Acta 1034:207-12 (1990). Read more (PubMed: 2162210) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"