製品の概要

  • 製品名Anti-CIITA antibody
    CIITA 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CIITA
  • アプリケーション適用あり: WB, ELISA, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-333 of Human CIITA

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.01% Sodium azide
  • 精製度Whole antiserum
  • 特記事項(精製)This product was prepared from monospecific antiserum by delipidation and defibrination.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab28349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Detects a band of approximately 130 kDa (predicted molecular weight: 125 kDa).
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

ターゲット情報

  • 機能Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).
  • 関連疾患Bare lymphocyte syndrome 2
  • 配列類似性Contains 4 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • ドメインThe acetyltransferase domain is necessary for activation of both class I and class II transcription.
    The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization.
  • 翻訳後修飾Autophosphorylated, affecting interaction with TAF7.
  • 細胞内局在Nucleus. Nucleus, PML body. Recruited to PML body by PML.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C2TA antibody
    • C2TA_HUMAN antibody
    • CIITA antibody
    • CIITA IV antibody
    • Class II major histocompatibility complex transactivator antibody
    • Class II transactivator antibody
    • MHC class II transactivator antibody
    • MHC class II transactivator type III antibody
    • MHC2TA antibody
    • NLR family acid domain containing antibody
    • NLRA antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing antibody
    see all

Anti-CIITA antibody (ab28349) 使用論文

This product has been referenced in:
  • Casals C  et al. Lipopolysaccharide up-regulates MHC class II expression on dendritic cells through an AP-1 enhancer without affecting the levels of CIITA. J Immunol 178:6307-15 (2007). Mouse . Read more (PubMed: 17475859) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"