製品の概要

  • 製品名Anti-CHX10 antibody - ChIP Grade
    CHX10 一次抗体 製品一覧
  • 製品の詳細
    Sheep polyclonal to CHX10 - ChIP Grade
  • アプリケーション適用あり: WB, ChIP, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Cow, Human
  • 免疫原

    Recombinant fragment, corresponding to N terminal amino acids 1-131 of Human CHX10.

  • ポジティブ・コントロール
    • Rat or mouse retinal tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab16142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 46 kDa. Detects a band of approximately 46 kDa mouse and rat retinal tissue lysates.
ChIP Use at an assay dependent dilution. PubMed: 18272592
IHC-P Use at an assay dependent concentration. PubMed: 20459797

ターゲット情報

  • 機能Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.
  • 組織特異性Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.
  • 関連疾患Defects in VSX2 are the cause of microphthalmia isolated type 2 (MCOP2) [MIM:610093]; also known as isolated clinical anophthalmia. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.
    Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities (MCOPCTI) [MIM:610092].
    Defects in VSX2 are the cause of microphthalmia isolated with coloboma type 3 (MCOPCB3) [MIM:610092]; also known as isolated colobomatous microphthalmia 3. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).
  • 配列類似性Belongs to the paired homeobox family.
    Contains 1 CVC domain.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C elegans ceh 10 homeo domain containing homolog antibody
    • Ceh 10 homeo domain containing homolog (C. elegans) antibody
    • Ceh 10 homeo domain containing homolog antibody
    • Ceh 10 homeodomain containing homolog antibody
    • Ceh 10 homeodomain containing homolog (C. elegans) antibody
    • Ceh-10 homeodomain-containing homolog antibody
    • Ceh10 homeo domain containing homolog antibody
    • Ceh10 homeodomain containing homolog antibody
    • CHX 10 antibody
    • Homeobox protein CHX 10 antibody
    • Homeobox protein CHX10 antibody
    • HOX 10 antibody
    • HOX10 antibody
    • MCOP 2 antibody
    • MCOP2 antibody
    • MCOPCB 3 antibody
    • MCOPCB3 antibody
    • RET 1 antibody
    • RET1 antibody
    • Visual system homeobox 2 antibody
    • Vsx 2 antibody
    • Vsx2 antibody
    • VSX2_HUMAN antibody
    see all

Anti-CHX10 antibody - ChIP Grade 画像

  • Western blot analysis using ab161412 at 1 µg/ml on rat liver (A), rat retina tissue lysate (B), mouse liver (C) and mouse retina tissue lysate (D).

Anti-CHX10 antibody - ChIP Grade (ab16142) 使用論文

This product has been referenced in:
  • Rapicavoli NA  et al. The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC Dev Biol 10:49 (2010). IHC-P ; Mouse . Read more (PubMed: 20459797) »
  • Bharti K  et al. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135:1169-78 (2008). ChIP ; Mouse . Read more (PubMed: 18272592) »

See all 2 Publications for this product

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