Anti-CHREBP 抗体 (ab92809)
Key features and details
- Rabbit polyclonal to CHREBP
- Suitable for: IHC-P, WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-CHREBP antibody
CHREBP 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CHREBP -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WB, ICC/IFmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human CHREBP aa 800-900 (C terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.01% Sodium azide
Constituent: Tris citrate/phosphate -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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ChIP Related Products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab92809の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 95 kDa.
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ICC/IF |
1/100 - 1/500.
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特記事項 |
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IHC-P
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 95 kDa. |
ICC/IF
1/100 - 1/500. |
ターゲット情報
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機能
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. -
組織特異性
Expressed in liver, heart, kidney, cerebellum and intestinal tissues. -
関連疾患
Note=WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. -
配列類似性
Contains 1 basic helix-loop-helix (bHLH) domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 51085 Human
- Entrez Gene: 58805 Mouse
- Omim: 605678 Human
- SwissProt: Q9NP71 Human
- SwissProt: Q99MZ3 Mouse
- Unigene: 647055 Human
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別名
- carbohydrate response element binding protein antibody
- bHLHd14 antibody
- Carbohydrate responsive element binding protein antibody
see all
画像
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Anti-CHREBP antibody (ab92809) (anti CHREBP) + human hepatocyte lysate at 20 µg
Predicted band size: 95 kDa
5-10 second film exposure -
anti CHREBP staining CHREBP in human colon epithelium (40X) by immunohistochemistry.
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anti CHREBP staining CHREBP in human hepatocyte by Immunofluorescence. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).
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Immunohistochemistry analysis of mouse liver labeling CHREBP with ab92809. DAB with hematoxylin counterstain.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (10)
ab92809 は 10 報の論文で使用されています。
- Dong X et al. Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma. Cell Death Discov 7:14 (2021). PubMed: 33462196
- Xue M et al. Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism. Food Nutr Res 65:N/A (2021). PubMed: 33994911
- Owczarek A et al. Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules. Int J Mol Sci 22:N/A (2021). PubMed: 34948094
- Moore MC et al. Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model. Am J Physiol Endocrinol Metab 319:E133-E145 (2020). PubMed: 32459527
- Huang F et al. Long noncoding RNA CCAT1 inhibits miR-613 to promote nonalcoholic fatty liver disease via increasing LXRa transcription. J Cell Physiol N/A:N/A (2020). PubMed: 32413192
- Suzuki S et al. Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney. Endocr J 67:335-345 (2020). PubMed: 31813922
- Zhang Y et al. Trimetazidine improves hepatic lipogenesis and steatosis in non-alcoholic fatty liver disease via AMPK-ChREBP pathway. Mol Med Rep 22:2174-2182 (2020). PubMed: 32705195
- Zhan H et al. Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation. Aging (Albany NY) 12:11004-11024 (2020). PubMed: 32518215
- Zhang Y et al. Berberine reverses abnormal expression of L-type pyruvate kinase by DNA demethylation and histone acetylation in the livers of the non-alcoholic fatty disease rat. Int J Clin Exp Med 8:7535-43 (2015). PubMed: 26221297
- Erion DM et al. The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology 154:36-44 (2013). WB . PubMed: 23161873