製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-NKDGVLVDEFGLPQ
    • 領域202 to 215

関連製品

特性

Our Abpromise guarantee covers the use of ab45718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-CHMP5 antibody (ab31282)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • apoptosis-related protein PNAS-2
    • C9orf83
    • CGI 34
    • Charged multivesicular body protein 5
    • CHMP 5
    • CHMP family, member 5
    • chmp5
    • CHMP5_HUMAN
    • Chromatin modifying protein 5
    • Chromatin-modifying protein 5
    • Chromosome 9 open reading frame 83
    • HGNC:26942
    • HSPC177
    • hVps60
    • PNAS 2
    • SNF7 domain containing protein 2
    • SNF7 domain-containing protein 2
    • SNF7DC2
    • Vacuolar protein sorting 60
    • Vacuolar protein sorting-associated protein 60
    • Vps60
    see all
  • 機能Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
  • 配列類似性Belongs to the SNF7 family.
  • 細胞内局在Cytoplasm > cytosol. Endosome membrane. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
  • Information by UniProt

CHMP5 peptide (202-215) (ab45718) 使用論文

ab45718 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"