製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Chimaerin 2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide selective for Chimaerin 2 protein. The peptide was post-synthetically modified and conjugated to a carrier protein before used for immunization of rabbits.

  • ポジティブ・コントロール
    • Chimaerin 2 samples.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファー
    Constituents: Antibody stabilization buffer with preservative.
  • Concentration information loading...
  • 精製度
    Protein A purified
  • 特記事項(精製)
    ab59625 was affinity purified on an immobilized antigen based affinity chromatography.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa).

ターゲット情報

  • 関連性
    The Chimaerin gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, an SH2 domain and a Rho-GAP domain. This protein has GTPase-activating protein activity which is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Increased expression of this gene is associated with lymphomas and decreased expression of this gene is associated with high-grade gliomas and breast tumors. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • 細胞内局在
    Membrane; Peripheral membrane protein
  • 参照データベース
  • 別名
    • ARHGAP3 antibody
    • BCH antibody
    • Beta chimerin antibody
    • Chimaerin2 antibody
    • Chimerin (chimaerin) 2 antibody
    • Chimerin 2 antibody
    • CHN 2 antibody
    • CHN2 antibody
    • MGC138360 antibody
    • Rho GTPase activating protein 3 antibody
    • RHOGAP3 antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Paul C & Robaire B Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS One 8:e84354 (2013). WB ; Rat . Read more (PubMed: 24391944) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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