製品の概要

  • 製品名
    Chelerythrine chloride
  • 製品の詳細
    Cell-permeable, selective protein kinase C inhibitor. Apoptosis inducer.
  • 別名
    • 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride
    • Toddalin chloride
  • 生理活性の詳細

    Cell-permeable, selective inhibitor of protein kinase C (IC50 = 0.66 μM); Competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Activates MAPK pathways, independent of PKC inhibition. Inhibits BclXL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.

  • 精製度
    > 98%

製品の特性

    Chelerythrine chloride (ab120600) 使用論文

    This product has been referenced in:
    • Chan SL  et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem 278:20453-6 (2003). Read more (PubMed: 12702731) »
    • Lee SK  et al. Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J Biol Chem 273:19829-33 (1998). Read more (PubMed: 9677417) »

    See all 3 Publications for this product

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