製品の概要

  • 製品名
    Charybdotoxin
  • 製品の詳細
    K+ channel blocker
  • 生理活性の詳細
    Blocks KCa1.1 (large conductance Ca2+ activated K+, Slo) channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels.

製品の特性

参考文献

This product has been referenced in:
  • Grissmer S  et al. Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol 45:1227-34 (1994). Read more (PubMed: 7517498) »
  • Gimenez-Gallego G  et al. Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci U S A 85:3329-33 (1988). Read more (PubMed: 2453055) »
  • Miller C  et al. Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature 313:316-8 (0). Read more (PubMed: 2578618) »

See all 4 Publications for this product

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