製品の概要
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製品名Anti-CfPV2 E6 antibody
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製品の詳細Rabbit polyclonal to CfPV2 E6
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アプリケーション適用あり: WB, ELISAmore details
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種交差性交差種: Recombinant fragment
交差が予測される動物種: Other
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免疫原
A synthetic peptide corresponding to N terminal residues of Dog Canine CfPV2 E6 protein
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at -20ºC.
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バッファーPreservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
精製度Immunogen affinity purified
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特記事項（精製）ab93861 is purified by antigen specific affinity chromatography. Purity is >90%.
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab93861 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 15 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. | |
| ELISA | 1/2000 - 1/5000. |
ターゲット情報
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関連性CfPV2 is a novel canine papillomavirus. Papillomaviruses are highly host- and tissue-tropic, and are rarely transmitted between species. Papillomaviruses replicate exclusively in the basal layer of the body surface tissues. All known papillomavirus types infect a particular body surface, typically the skin or mucosal epithelium of the genitals, anus, mouth, or airways. CfPV2 induces papillomas on footpads and interdigital regions which, if infection is persistent, can progress to highly metastatic squamous cell carcinoma. CfPV2 does not induce oral papillomas in immunocompetent animals and antibodies generated against COPV and CfPV2 are type-specific. E6 is a 151 amino-acid peptide that incorporates a type 1 motif. E6 is of particular interest because it appears to have multiple roles in the cell and to interact with many other proteins. Its major role, however, is to mediate the degradation of p53, a major tumor suppressor protein, reducing the cell's ability to respond to DNA damage. Overall, the E6 protein serves to impede normal protein activity in such a way as to allow a cell to grow and multiply at the increased rate characteristic of cancer.
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参照データベース
- Entrez Gene: 5076447 Other
- SwissProt: Q647I1 Other
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別名
- CPV2 gp1 antibody
- E6 antibody
- Early protein E6 antibody
プロトコール
Anti-CfPV2 E6 antibody (ab93861) 使用論文
ab93861 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"