製品の概要

  • 製品名
    Anti-CFC1 antibody [MM0205-8D12]
    CFC1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0205-8D12] to CFC1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human recombinant CFC1

  • 特記事項
    Reconstituted antibody should be aliquoted and can be stored frozen at < -20°C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

製品の特性

  • 製品の状態
    Lyophilised:Reconstitute the antibody with 200 µl sterile PBS to give a final concentration of 0.5mg/ml.
  • 保存方法
    Shipped at 4°C. Store at -80°C.
  • バッファー
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度
    Protein G purified
  • 特記事項(精製)
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography.
  • ポリ/モノ
    モノクローナル
  • クローン名
    MM0205-8D12
  • アイソタイプ
    IgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 25 kDa.

ターゲット情報

  • 機能
    NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.
  • 関連疾患
    Heterotaxy, visceral, 2, autosomal (HTX2) [MIM:605376]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Transposition of the great arteries dextro-looped 2 (DTGA2) [MIM:613853]: A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 配列類似性
    Contains 1 EGF-like domain.
  • 翻訳後修飾
    N-glycosylated.
  • 細胞内局在
    Cell membrane. Secreted. Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CFC 1 antibody
    • CFC1 antibody
    • CFC1_HUMAN antibody
    • CFC1B antibody
    • CR 1 antibody
    • Cripto 1 antibody
    • Cripto FRL 1 cryptic family 1 antibody
    • CRYPTIC antibody
    • Cryptic family 1 antibody
    • Cryptic family protein 1 antibody
    • Cryptic gene antibody
    • Cryptic protein antibody
    • DTGA2 antibody
    • FLJ77897 antibody
    • FRL 1 antibody
    • Heterotaxy 2 (autosomal dominant) antibody
    • HTX2 antibody
    • MGC133213 antibody
    see all

プロトコール

参考文献

ab89193 has not yet been referenced specifically in any publications.

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