The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報Depletion: Use at an assay dependent dilution.
ELISA: 1/200 - 1/500.
WB: 1/1000. Predicted molecular weight: 122 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
組織特異性Expressed by the liver and secreted in plasma.
関連疾患Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
配列類似性Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 6 plastocyanin-like domains.