製品の概要

  • 製品名Anti-Ceruloplasmin antibody
    Ceruloplasmin 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Ceruloplasmin
  • 特異性By immunoelectrophoresis and ELISA this antibody reacts specifically with ceruloplasmin. No antibody was detected against other serum proteins.
  • アプリケーション適用あり: WB, ELISA, ICCmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Unfortunately, this information is considered to be commercially sensitive

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab19171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 122 kDa.
ELISA 1/100 - 1/1000.
ICC 1/200 - 1/2000.

ターゲット情報

  • 機能Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
  • 組織特異性Expressed by the liver and secreted in plasma.
  • 関連疾患Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
  • 配列類似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CERU_HUMAN antibody
    • Ceruloplasmin antibody
    • CP 2 antibody
    • CP antibody
    • CP2 antibody
    • Ferroxidase antibody
    see all

Anti-Ceruloplasmin antibody (ab19171) 使用論文

This product has been referenced in:
  • Hatori Y  et al. Functional partnership of the copper export machinery and glutathione balance in human cells. J Biol Chem 287:26678-87 (2012). WB ; Mouse . Read more (PubMed: 22648419) »
  • Mittag J  et al. Serum copper as a novel biomarker for resistance to thyroid hormone. Biochem J 443:103-9 (2012). WB . Read more (PubMed: 22220593) »

See all 3 Publications for this product

Product Wall

Thank you for your patience. I am afraid that the originator of the product can only confirm that the antibody was made with the whole protein and not a synthesized peptide, and that the goat was immunized with native protein ceruloplasmin. I am ...

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Thank you for your enquiry. Ab8749 is a polyclonal antibody raised to the full length protein, and will therefore consist of a mixed population of IgGs, each of which will recognise a different epitope. The immunogen for Ab19171 is considered c...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"