製品の概要

  • 製品名Anti-CEP290 antibody
    CEP290 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CEP290
  • アプリケーション適用あり: ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 2429 and 2479 of human CEP290 (NP_079390.3).

  • ポジティブ・コントロール
    • Human HeLa cells

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified using an epitope specific to CEP290 immobilized on solid support. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/100 - 1/500. Fix with formaldehyde. Acetone fixation is not recommended.

ターゲット情報

  • 機能Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.
  • 組織特異性Ubiquitous. Expressed strongly in placenta and weakly in brain.
  • 関連疾患Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188]. Joubert syndrome is an autosomal recessive disease characterized by cerebellar vermis hypoplasia with prominent superior cerebellar peduncles (the 'molar tooth sign' on axial magnetic resonance imaging), psychomotor delay, hypotonia, ataxia, oculomotor apraxia and neonatal breathing abnormalities. JBTS5 shares the neurologic and neuroradiologic features of Joubert syndrome together with severe retinal dystrophy and/or progressive renal failure characterized by nephronophthisis.
    Defects in CEP290 are a cause of Senior-Loken syndrome type 6 (SLSN6) [MIM:610189]. Senior-Loken syndrome is also known as juvenile nephronophthisis with Leber amaurosis. It is an autosomal recessive renal-retinal disorder, characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease.
    Defects in CEP290 are the cause of Leber congenital amaurosis type 10 (LCA10) [MIM:611755]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
    Defects in CEP290 are the cause of Meckel syndrome type 4 (MKS4) [MIM:611134]. MKS4 is an autosomal recessive disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.
    Note=Antibodies against CEP290 are present in sera from patients with cutaneous T-cell lymphomas, but not in the healthy control population.
    Defects in CEP290 are the cause of Bardet-Biedl syndrome type 14 (BBS14) [MIM:209900]. A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for disease manifestation in some cases (triallelic inheritance).
  • 細胞内局在Cytoplasm > cytoskeleton > centrosome. Nucleus. Cell projection > cilium. Connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3H11AG antibody
    • Bardet-Biedl syndrome 14 protein antibody
    • BBS14 antibody
    • Cancer/testis antigen 87 antibody
    • CE290_HUMAN antibody
    • Centrosomal protein 290kDa antibody
    • Centrosomal protein of 290 kDa antibody
    • Cep290 antibody
    • CT87 antibody
    • CTCL tumor antigen se2 2 antibody
    • FLJ13615 antibody
    • FLJ21979 antibody
    • JBTS5 antibody
    • JBTS6 antibody
    • KIAA0373 antibody
    • LCA10 antibody
    • Meckel syndrome, type 4 antibody
    • MKS4 antibody
    • Monoclonal antibody 3H11 antigen antibody
    • Nephrocystin 6 antibody
    • Nephrocystin-6 antibody
    • NPHP6 antibody
    • POC3 antibody
    • POC3 centriolar protein homolog antibody
    • Prostate cancer antigen T21 antibody
    • rd16 antibody
    • SLSN6 1, 2, 5 antibody
    • SLSN6 antibody
    • Tumor antigen se2-2 antibody
    see all

Anti-CEP290 antibody 画像

  • Staining of human CEP290 in NBF fixed asynchronous HeLa cells by Immunocytochemistry, using ab84870 at a dilution of 1/250. Detection: Red fluorescent goat anti-rabbit IgG used at a dilution of 1/100.

Anti-CEP290 antibody (ab84870) 使用論文

This product has been referenced in:
  • Silva E  et al. Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry. Mol Biol Cell 27:48-63 (2016). ICC/IF ; Human . Read more (PubMed: 26538025) »
  • Hoang-Minh LB  et al. PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. Transl Oncol 9:392-402 (2016). Human . Read more (PubMed: 27661404) »

See all 10 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab84870.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"