製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to CENTB1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide: EKLSRRSHDLHTL, corresponding to C terminal amino acids 728-740 of Human CENTB1.

  • ポジティブ・コントロール
    • Jurkat lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab15903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 80-90 kDa (predicted molecular weight: 85 kDa).Can be blocked with Human CENTB1 peptide (ab23280).

ターゲット情報

  • 機能
    GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.
  • 組織特異性
    Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
  • 配列類似性
    Contains 3 ANK repeats.
    Contains 1 Arf-GAP domain.
    Contains 1 BAR domain.
    Contains 1 PH domain.
  • ドメイン
    PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.
  • 翻訳後修飾
    Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ACAP 1 antibody
    • ACAP1 antibody
    • ACAP1_HUMAN antibody
    • Arf GAP with coiled coil ANK repeat and PH domains 1 antibody
    • Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1 antibody
    • Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 antibody
    • ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 antibody
    • CENT B1 antibody
    • Centaurin beta 1 antibody
    • Centaurin-beta-1 antibody
    • CENTB 1 antibody
    • Cnt b1 antibody
    • Cnt-b1 antibody
    • Cntb1 antibody
    • KIAA0050 antibody
    see all

画像

  • Anti-CENTB1 antibody (ab15903) at 1 µg/ml + Jurkat cell lysate at 35 µg

    Predicted band size : 85 kDa
    Additional bands at : 80 kDa. We are unsure as to the identity of these extra bands.

    Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

     

     

プロトコール

参考文献

ab15903 has not yet been referenced specifically in any publications.

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