製品の概要

  • 製品名
    Celastrol from Celastrus scandens
  • 製品の詳細
    Anti-inflammatory and antiproliferative agent
  • 別名
    • Tripterine
  • 生理活性の詳細
    Anti-inflammatory and antiproliferative effects (IC50 = 2.12 µM). Able to modulate multiple cell-signaling pathways (inhibits NF-κB, upregulates cytoplasmic HSP70 and HSP27, suppress VEGF/Akt/mTOR pathways and inhibits TNF-α, proteasome inhibitor).
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Mou H  et al. Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways. Toxicol In Vitro 25:1027-32 (2011). Read more (PubMed: 21466843) »
  • Hansen J  et al. Quantitative proteomics reveals cellular targets of celastrol. PLoS One 6:e26634 (2011). Read more (PubMed: 22046318) »
  • Kannaiyan R  et al. Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett 303:9-20 (2011). Read more (PubMed: 21168266) »
  • Dai Y  et al. Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB. PLoS One 5:e14153 (2010). Read more (PubMed: 21170316) »
  • Allison AC  et al. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 25:1341-57 (2001). Read more (PubMed: 11513350) »
  • Bond J  et al. Care of the elderly: nursing homes and continuing care. Part III. Nurs Stand 4:35-7 (0). Read more (PubMed: 2116826) »

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