製品の概要

  • 製品名CDPPB
  • 製品の詳細
    PAM for mGlu5. Active in vivo.
  • 生理活性の詳細Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic in vivo.
  • 精製度> 98%

法規制情報

製品の特性

    CDPPB (ab120363) 使用論文

    This product has been referenced in:
    • Chen Y  et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol 71:1389-98 (2007). Read more (PubMed: 17303702) »
    • Kinney GG  et al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther 313:199-206 (2005). Read more (PubMed: 15608073) »
    • Uslaner JM  et al. Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus. Neuropharmacology 57:531-8 (0). Read more (PubMed: 19627999) »

    See 0 Publications for this product

    Product Wall

    Thank you for contacting Abcam.For storage purposes we do have the following recommendation on the datasheet " Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we ...

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    We don’t have any other PAMs available at the moment. Other alternatives which may be of useinclude:

    ab120039 (R,S)-CHPG Selective mGlu5 agonist
    ab120221 (R,S)-CHPG sodium salt Selective mGlu5 agonist
    I hope this is helpful. P...

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    Thank you for your reply.

    I have sent you a new vial of ab120363 and hopefully by storing the product as stated in the previous email, the product will remain stable for longer. Your new Abcam order/reference number is *********.

    If...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"