CDPPB, positive allosteric modulator for mGlu5 (ab120363)
Key features and details
- PAM for mGlu5. Active in vivo.
- CAS Number: 781652-57-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
CDPPB, positive allosteric modulator for mGlu5 -
製品の詳細
PAM for mGlu5. Active in vivo. -
生理活性の詳細
Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic in vivo.
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CAS 番号
781652-57-1 -
構造式
製品の特性
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体系名
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide -
分子量
364.41 -
分子式
C23H16N4O -
PubChem 登録番号
11245456 -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
N#Cc1cccc(c1)C(=O)Nc3cc(nn3c2ccccc2)c4ccccc4 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab120363 は論文での使用が確認できていません。