製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CDK1
  • アプリケーション
    適用あり: WB, IPmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Recombinant full length Human Cdc2 protein with His tag.

  • ポジティブ・コントロール
    • K562, Jurkat and C6 cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab71939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報
    IP: Use at a concentration of 2.5 µl/ml of lysate.
    WB: 1/2000. Detects a band of approximately 30 kDa (predicted molecular weight: 34 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
    • 組織特異性
      Isoform 2 is found in breast cancer tissues.
    • 配列類似性
      Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
      Contains 1 protein kinase domain.
    • 細胞内局在
      Nucleus.
    • Information by UniProt
    • 参照データベース
    • 製品の状態
      CDK1 can be located to the Nucleus, cytoplasm and Mithocondria. It's cytoplasmic during interphase and reversibly translocated from cytoplasm to the nucleus when phosphorilated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
    • 別名
      • Cdc 2 antibody
      • Cdc2 antibody
      • CDC28A antibody
      • CDK 1 antibody
      • CDK1 antibody
      • CDK1_HUMAN antibody
      • CDKN1 antibody
      • CELL CYCLE CONTROLLER CDC2 antibody
      • Cell division control protein 2 antibody
      • Cell division control protein 2 homolog antibody
      • Cell division cycle 2 G1 to S and G2 to M antibody
      • Cell division protein kinase 1 antibody
      • Cell Divsion Cycle 2 Protein antibody
      • Cyclin Dependent Kinase 1 antibody
      • Cyclin-dependent kinase 1 antibody
      • DKFZp686L20222 antibody
      • MGC111195 antibody
      • p34 Cdk1 antibody
      • p34 protein kinase antibody
      • P34CDC2 antibody
      see all

    画像

    • All lanes : Anti-CDK1 antibody (ab71939) at 1/2000 dilution

      Lane 1 : K562 cell lysate
      Lane 2 : Jurkat T cell lysate
      Lane 3 : C6 cell lysate


      Predicted band size : 34 kDa
      Observed band size : 30 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 35 kDa,62 kDa. We are unsure as to the identity of these extra bands.

    参考文献

    This product has been referenced in:

    See 1 Publication for this product

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