製品の概要

  • 製品名Anti-Cdc34 antibody
    Cdc34 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to Cdc34
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    N-terminally 6x-His tagged fusion protein encoding full-length human Cdc34 expressed in E. coli.

  • ポジティブ・コントロール
    • 293 cells and recombinant fusion protein.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報Immunoblotting and immunoprecipitation.
  • ターゲット情報

    • 機能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase throught its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
    • 組織特異性Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.
    • パスウェイProtein modification; protein ubiquitination.
    • 配列類似性Belongs to the ubiquitin-conjugating enzyme family.
    • ドメインThe C-terminal acidic tail is required for nuclear localization and is involved in the binding to SCF E3 ligase complexes, and more specifically with the CUL1 subunit.
    • 翻訳後修飾Autoubiquitinated. Autoubiquitination is promoted by the human herpes virus 1 protein ICP0 and leads to degradation by the Ubiquitin-proteasomal pathway.
      Phosphorylated by CK2. Phosphorylation of the C-terminal tail by CK2 controles the nuclear localization.
    • 細胞内局在Cytoplasm. Nucleus. The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cdc 34 antibody
      • Cdc34 antibody
      • Cell division cycle 34 antibody
      • Cell division cycle 34 homolog (S. cerevisiae) antibody
      • Cell division cycle 34 homolog antibody
      • E2 CDC34 antibody
      • UB2R1_HUMAN antibody
      • UBC 3 antibody
      • UBC3 antibody
      • UBCH3 antibody
      • UBE2 R1 antibody
      • UBE2R1 antibody
      • Ubiquitin carrier protein antibody
      • Ubiquitin conjugating enzyme Cdc34 antibody
      • Ubiquitin conjugating enzyme E2 32 kDa complementing antibody
      • Ubiquitin protein ligase antibody
      • Ubiquitin protein ligase R1 antibody
      • Ubiquitin-conjugating enzyme E2 R1 antibody
      • Ubiquitin-conjugating enzyme E2-32 kDa complementing antibody
      • Ubiquitin-conjugating enzyme E2-CDC34 antibody
      • Ubiquitin-protein ligase R1 antibody
      see all

    Anti-Cdc34 antibody (ab482) 使用論文

    ab482 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"