製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CDC2L5
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 281-310 of Mouse CDC2L5.

  • ポジティブ・コントロール
    • Mouse testis tissue lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 165 kDa.

ターゲット情報

  • 機能
    Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
  • 組織特異性
    Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
  • 配列類似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Nucleus speckle.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CDC2 related protein kinase 5 antibody
    • CDC2-related protein kinase 5 antibody
    • CDC2L antibody
    • CDK13 antibody
    • CDK13_HUMAN antibody
    • cell division controller cholinesterase related antibody
    • cell division cycle 2 like 5 (cholinesterase related cell division controller) antibody
    • cell division cycle 2 like 5 antibody
    • Cell division cycle 2 like protein kinase 5 antibody
    • Cell division cycle 2-like protein kinase 5 antibody
    • Cell division protein kinase 13 antibody
    • CHED antibody
    • Cholinesterase related cell division controller antibody
    • Cholinesterase-related cell division controller antibody
    • cyclin dependent kinase 13 antibody
    • Cyclin-dependent kinase 13 antibody
    • hCDK13 antibody
    see all

画像

  • Anti-CDC2L5 antibody (ab124101) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

    Predicted band size : 165 kDa

プロトコール

参考文献

ab124101 has not yet been referenced specifically in any publications.

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