Anti-Cdc25B (phospho S353) 抗体 (ab59431)

製品の概要

  • 製品名Anti-Cdc25B (phospho S353) antibody
    Cdc25B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Cdc25B (phospho S353)
  • 特異性Detects endogenous levels of Cdc25B only when phosphorylated at serine 353.
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic phosphopeptide derived from human CdC25B around the phosphorylation site of serine 353 (R-R-SP-V-T).

  • ポジティブ・コントロール
    • Brain tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab59431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/40000.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
  • 配列類似性Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.
  • 翻訳後修飾Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
  • 細胞内局在Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI604853 antibody
    • Cdc 25B antibody
    • Cdc25b antibody
    • CDC25HU2 antibody
    • Cdc25m2 antibody
    • Cell division cycle 25 homolog B antibody
    • Cell division cycle 25B antibody
    • Cell division cycle 25B isoform 1 antibody
    • Cell division cycle 25B isoform 2 antibody
    • Cell division cycle 25B isoform 3 antibody
    • Cell division cycle 25B isoform 4 antibody
    • Cell division cycle 25B isoform 5 antibody
    • Dual specificity phosphatase Cdc25B antibody
    • EC 3.1.3.48 antibody
    • M phase inducer phosphatase 2 antibody
    • M-phase inducer phosphatase 2 antibody
    • MPIP2_HUMAN antibody
    see all

Anti-Cdc25B (phospho S353) antibody 画像

  • ab59431, at a 1/50 dilution, staining paraffin embedded human brain tissue sections by Immunohistochemistry in the absence (left image) or presence (right image) of the phosphopeptide.

Anti-Cdc25B (phospho S353) antibody (ab59431) 使用論文

ab59431 has not yet been referenced specifically in any publications.

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