Anti-CD86 抗体 [BU63] (Phycoerythrin) (ab77226)
製品の概要
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製品名Anti-CD86 antibody [BU63] (Phycoerythrin)
CD86 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [BU63] to CD86 (Phycoerythrin)
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標識Phycoerythrin. Ex: 488nm, Em: 575nm
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特異性ab77226 reacts with CD86 expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
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アプリケーション適用あり: Flow Cytmore details
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種交差性交差種: Human
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免疫原
B-lymphoblastoid cell line ARH 77
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特記事項
The antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C.
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バッファーPreservative: 15mM Sodium Azide
Constituents: 0.2% BSA, PBS -
Concentration information loading... -
精製度Size exclusion
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特記事項（精製）The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
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ポリ/モノモノクローナル
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クローン名BU63
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アイソタイプIgG1
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab77226 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
追加情報
Flow Cyt: The reagent is designed for Flow Cytometry analysis of human blood cells
Use 20 µl/100 µl of whole blood or 106 cells in a suspension.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Use 20 µl/100 µl of whole blood or 106 cells in a suspension.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
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組織特異性Expressed by activated B-lymphocytes and monocytes.
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配列類似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻訳後修飾Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
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細胞内局在Membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 942 Human
- Omim: 601020 Human
- SwissProt: P42081 Human
- Unigene: 171182 Human
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別名
- Activation B7-2 antigen 3 antibody
- Activation B7-2 antigen antibody
- B-lymphocyte activation antigen B7-2 2 antibody
see all
Anti-CD86 antibody [BU63] (Phycoerythrin) 画像
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![Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)](http://a.abcam.com/ps/products/77/ab77226/Images/ab77226-273615-77226.JPG)
Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)Analysis by flow cytometry of ab77226 staining CD86 in human peripheral blood cells.
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![Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)](http://a.abcam.com/ps/products/77/ab77226/Images/CD86-Primary-antibodies-ab77226-1.jpg)
Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)Flow cytometry analysis of human peripheral blood leukocytes with anti-human CD86 (BU63) PE.
プロトコール
Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226) 使用論文
This product has been referenced in:
- Giguère JF et al. Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle. J Virol 78:6222-32 (2004). Read more (PubMed: 15163715) »
- Mauri D et al. Antigen-presenting T cells induce the development of cytotoxic CD4+ T cells. I. Involvement of the CD80-CD28 adhesion molecules. J Immunol 155:118-27 (1995). Read more (PubMed: 7541409) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"