製品の概要

  • 製品名
    Anti-CD86 antibody [BU63] (Phycoerythrin)
    CD86 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [BU63] to CD86 (Phycoerythrin)
  • 由来種
    Mouse
  • 標識
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特異性
    ab77226 reacts with CD86 expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
  • アプリケーション
    適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    B-lymphoblastoid cell line ARH 77

  • 特記事項

    The antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報
    Flow Cyt: The reagent is designed for Flow Cytometry analysis of human blood cells
    Use 20 µl/100 µl of whole blood or 106 cells in a suspension.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • ターゲット情報

    • 機能
      Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
    • 組織特異性
      Expressed by activated B-lymphocytes and monocytes.
    • 配列類似性
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 翻訳後修飾
      Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
    • 細胞内局在
      Membrane.
    • Information by UniProt
    • 参照データベース
      • 別名
        • Activation B7-2 antigen 3 antibody
        • Activation B7-2 antigen antibody
        • B-lymphocyte activation antigen B7-2 2 antibody
        • B-lymphocyte activation antigen B7-2 antibody
        • B7 2 antibody
        • B7 antibody
        • B7-2 antibody
        • B7.2 antibody
        • B70 antibody
        • B72 antigen antibody
        • BU63 antibody
        • CD28 antigen ligand 2 2 antibody
        • CD28 antigen ligand 2 antibody
        • Cd28l2 antibody
        • CD28LG2 antibody
        • CD86 antibody
        • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2 antibody
        • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) antibody
        • CD86 antigen antibody
        • CD86 molecule antibody
        • CD86_HUMAN antibody
        • CLS1 antibody
        • CTLA-4 counter-receptor B7.2 2, 3 antibody
        • CTLA-4 counter-receptor B7.2 antibody
        • Early T-cell costimulatory molecule 1 antibody
        • ETC-1 antibody
        • FUN 1 antibody
        • FUN-1 antibody
        • LAB72 antibody
        • Ly-58 antibody
        • Ly58 antibody
        • MB7 antibody
        • MB7-2 antibody
        • Membrane glycoprotein antibody
        • MGC34413 antibody
        • T-lymphocyte activation antigen CD86 antibody
        • TS/A-2 antibody
        see all

      画像

      • Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)
        Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)

        Analysis by flow cytometry of ab77226 staining CD86 in human peripheral blood cells.

      • Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)
        Flow Cytometry - Anti-CD86 antibody [BU63] (Phycoerythrin) (ab77226)
        Flow cytometry analysis of human peripheral blood leukocytes with anti-human CD86 (BU63) PE. 

      プロトコール

      参考文献

      This product has been referenced in:
      • Giguère JF  et al. Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle. J Virol 78:6222-32 (2004). Read more (PubMed: 15163715) »
      • Mauri D  et al. Antigen-presenting T cells induce the development of cytotoxic CD4+ T cells. I. Involvement of the CD80-CD28 adhesion molecules. J Immunol 155:118-27 (1995). Read more (PubMed: 7541409) »

      See all 4 Publications for this product

      ab77226 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

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