製品の概要

  • 製品名
    Anti-CD8 beta antibody [341]
    CD8 beta 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [341] to CD8 beta
  • アプリケーション
    適用あり: IHC-P, Flow Cyt, IP, WBmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Rat/mouse T cell hybrids expressing CD8.

  • ポジティブ・コントロール
    • Lou rat splenocytes and thymocytes.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    モノクローナル
  • クローン名
    341
  • アイソタイプ
    IgG1
  • 軽鎖の種類
    kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
Flow Cyt
IP
WB
  • 追加情報
    Flow Cyt: Use 0.5µg for 106 cells.
    IHC-P: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 24 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
    • 組織特異性
      Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
    • 配列類似性
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 翻訳後修飾
      Phosphorylated as a consequence of T-cell activation.
    • 細胞内局在
      Secreted and Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CD8b antigen antibody
      • CD8 antigen beta polypeptide 1 (p37) antibody
      • CD8 antigen beta polypeptide 1 antibody
      • CD8 beta antibody
      • CD8b antibody
      • CD8b molecule antibody
      • CD8B_HUMAN antibody
      • CD8B1 antibody
      • Leu2 antibody
      • Ly3 antibody
      • LYT3 antibody
      • MGC119115 antibody
      • P37 antibody
      • T cell surface glycoprotein CD8 beta chain antibody
      • T lymphocyte surface glycoprotein beta chain antibody
      • T-cell surface glycoprotein CD8 beta chain antibody
      see all

    画像

    • Staining of Lou rat splenocytes with 0.25 µg of Purified Mouse IgG1, K Isotype Control (open histogram) or 0.25 µg of ab90965 (colored histogram) followed by Biotin Anti-Mouse IgG. Cells in the lymphocyte gate were used for analysis.

    参考文献

    This product has been referenced in:
    • Hirji N  et al. Mechanisms of macrophage stimulation through CD8: macrophage CD8alpha and CD8beta induce nitric oxide production and associated killing of the parasite Leishmania major. J Immunol 160:6004-11 (1998). Read more (PubMed: 9637515) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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